1/13/2024 0 Comments Grapefruit juice and lisinoprilWhile these studies suggest potential benefits of drinking grapefruit juice for people with diabetes, more research is needed to confirm these findings in humans. The researchers believe that this result was due to compounds in the grapefruit juice suppressing glucose production in the rat’s livers. In a 2015 study, rats with drug-induced diabetes that drank grapefruit juice for 60 days experienced a decrease in fasting blood sugar levels compared to those that just drank water. The researchers stated that the mice drank the equivalent 3.5 to 4 cups of grapefruit juice a day for an average 70 kg adult person. However, the mice on the low-fat diet only experienced a decrease in fasting blood insulin levels. The study found the mice on the high-fat diet experienced falls in fasting blood sugar levels, fasting blood insulin levels, and body weight compared to mice that did not drink grapefruit juice. In a 2014 study, researchers gave 25 to 50 percent sweetened grapefruit juice preparations to healthy mice that were on either a high-fat diet or low-fat diet. Researchers do not fully understand why, but compounds in grapefruit may help lower blood sugar levels. Because of these effects, many drug labels recommend not using grapefruit product during treatment.Share on Pinterest Drinking grapefruit juice may be beneficial to people with diabetes.Īlthough grapefruit contains sugar, there is some evidence to suggest that consuming this fruit may be good for people with diabetes. Furthermore, there are some medications that are affected by grapefruit in such as way that their absorption is increased leading to medication toxicity and over-dosage. It can either decrease the total drug serum levels or prolong the time needed for the medication take effect. So if Lisinopril & Grapefruit are ok, why is Grapefruit not recommend with other drugs?īasically, grapefruit contains potent chemicals that can affect or block the absorption of a lot of medications. For more specific information, you should consult your physician. Generally, doctors advise their patients to consult them first before taking any high acidic fruits, vegetables and other food products with your medication. If that is the case with you or someone you know, then grapefruit should not consumed. These types of medications are known to interact with grapefruit. People who are prescribed Lisinopril are often, also prescribed other medications concurrently such as statins and angiotensin II receptor antagonists. Some would warn you about the negative effects of taking lisinopril and grapefruit while others would not really mention any untoward interactions between these compounds.īecause of the varying recommendations, it is recommended that you consult your physician whether you should avoid grapefruit or not while on lisinopril. If you ask a group of physicians prescribing lisinopril, you’d likely get different opinions. Healthcare providers, too, have contrasting opinions when it comes to lisinopril and grapefruit. While these claims do not have substantial evidence and background studies, it is best to be warned and stay safe. However, there are some resources suggesting that grapefruit could potentially increase the patient’s blood pressure (contradicting the desired effect of lisinopril which is to lower blood pressure). Since there are no proven studies that show interaction between grapefruit and lisinopril, you can theoretically consume grapefruit while on lisinopril treatment without any adverse effects. Should grapefruit be avoided when taking lisinopril?Īt present, there are no studies that prove any interaction between grapefruit juice and ACE-inhibitors including lisinopril although such drug-food interaction is possible with another group of medications closely linked with ACE-inhibitors – the angiotensin II type receptor antagonists (such as losartan and valsartan). One commonly asked question by consumers is whether or not they can safely consume Grapefruit, grapefruit juice and other grapefruit products while on Lisinopril. Like any other medications, lisinopril has some known drug and food interactions hence, taking these substances together must be avoided. ACE inhibitors relax the blood vessels by blocking the production of a vital chemical called angiotensin-converting enzyme. Lisinopril belongs to a group of medication called angiontensin-converting enzyme (ACE) inhibitors.
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